North of England Irish Terrier Club
Founded 1906

CYSTINURIA IN IRISH TERRIERS

Cystinuria is a rare condition -we are appealing for small blood samples (with veterinary reports and pedigrees) from affected Irish Terriers that we will facility forwarding to Dr Prof Leeb's department at University of Berne, Switzerland.

Research is underway to find a gene variant that is associated with genetic predisposition to the condition and develop a genetic test that can be used by breeders to ensure that no more Irish Terriers are bred that develop the condition.

The UK breed clubs are keen to do anything we can to facility this research and the Welfare Fund, administered by the the Irish Terrier Association (ITA) is available to to pay owners' veterinary fees for obtaining the samples. We are grateful to Dr June Swinburne,of Animal DNA diagnositics for the initial processing of samples. If you think you can help please contact the ITA secretary who will give details of exactly what we need:

Miss Ann Bradley, Tel: 01733 205386    email montelle@btinternet.com

Please ensure that any stones removed are retained for possible analysis.



Notes about the condition

compiled by Ron Punter

Cystine is a derivative of one of the twenty amino acids that are the building blocks of life - cysteine.

Residual amino acids are usually filtered out and recycled by the kidneys.

When cystine is not being filtered properly it can form into stones (calculi, uroliths) in the kidneys, ureters and bladder. Small stones may pass out of the bladder and through the urinary tract, this can be very painful and there is a high chance of a blockage occurring.

""If there is any change in behaviour or other sign that your dog's urinary tract is blocked or is having trouble urinating, call your veterinarian immediately or go to an emergency clinic if it's after hours, as this is an emergency situation that cannot wait."

Cystinuria is relatively rare and many vets are not aware of it and mistake it for the much more common stones formed from struvites (magnesium ammonium phosphate crystals) caused by a urinary tract infection.

Typically the type of cystinuria that sometimes affects Irish Terriers is late onset about four years old onward.

A laboratory test can determine the levels of amino acids in urine - Cystine, Ornithine, Lysine, and Arginine (COLA test) -though it's only cystine that causes a problem. Fairly obviously, high COLA levels mean the dog is at risk of Cystinuria.

Cystinuria in humans is a genetic recessive trait and it is often misquoted as being the same in dogs but in fact there are several different defective genes which are now put into three divisions- in some breeds it is indeed recessive- designated type1 but in some others it's dominant -designated type2. In Irish Terriers (and Scottish Deerhounds) the condition only occurs in male dogs that have not been neutered - designated type3, this is thought to be testosterone (male hormone) dependent and genetically autosomal (not on X chromosome in the way that sex linked conditions often are.) It is not yet known if the mode of inheritance is dominant or recessive.

Surgical and medical castration cures type III cystinuria (assuming stones have been removed.)
Surgical castration is a complete lifetime cure.
Hormone implant castration works for as long as the chip is effective.
See: http://www.virbac.co.uk/suprelorin
Chemical castration may only reduce testosterone by about half and may not be effective in preventing androgen dependent diseases such as type III cystinuria.
Medical management is not highly effective.
BARF (raw food), high protein diets, chicken and salmon seem to favour stone formation.

Following surgical castration and recovery period of a couple of months and one urinary COLA test there is no need for medical treatment, any special diets or monitoring. A regular canine diet will be fine, just not a high protein diet. (Note a BARF diet is high protein.)

References:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946761/
SLC3A1 and SLC7A9 Mutations in Autosomal Recessive or Dominant Canine Cystinuria: A New Classification System
A.-K. Brons,† P. S. Henthorn,† K. Raj,† C. A. Fitzgerald,† J. Liu,† A. C. Sewell,§ and U. Giger†

https://sdcahealth.wordpress.com/health-issues/cystinuria/
Scottish Deerhound Club of America -Cystinuria





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